I think everyone has played Rock, Paper, Scissors. Sheldon and the rest of the guys from The Big Bang Theory play it a little differently. They like to play Rock, Paper, Scissors, Lizard, Spock. Here are the rules if you are not familiar with them:
Scissors cuts paper
Paper covers rock
Rock crushes lizard
Lizard poisons Spock
Spock smashes scissors
Scissors decapitate lizard
Lizard eats paper
Paper disproves Spock
Spock vaporizes rock
Rock crushes scissors
And the accompanying hand gestures:
Make sure you check out this video!
Have you picked up your copy of the complete first and second season on Blu-Ray combo pack yet?
Disclosure: I have been hired by Warner Brothers WBWord division to raise awareness of "The Big Bang Theory".